Method | Index - HPRC | Query - HLA Locus |
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Size (GB) | Pivot | Query Length | Query Type | Time | Memory (GB) |
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PanKmer | 23.29 | any | 31-mer only | 1, –, 3, – | 1:54:43.45 | 8.04 |
KMC3-M | 1,267.20 | any | re-index | 1, 2, 3, – | 0:49:15.49 | 13.99 |
KMC3-C | 18.05 | any | re-index | 1, –, 3, 4* | 0:00:38.59 | 17.68 |
MEMO-M | 1.94 | re-index | any | 1, 2, 3, – | 0:00:59.60 | 3.51 |
MEMO-C | 1.67 | re-index | any | 1, –, 3, – | 0:00:08.26 | 3.51 |
MEMO-DC | 0.76 | re-index | any | –, –, –, 4 | 0:00:06.16 | 3.26 |
- The pangenome includes 88 human autosomal haplotypes from HPRC and GRCh38. Regions of Ns on GRCh38 are masked. Index query types include: 1. Global presence/absence; 2. Member presence/absence; 3. Conservation; 4. Decile conservation. Query type 4* indicates no relative size reduction in a KMC3 decile index. The decile conservation index yields counts to the nearest lowest decile. Elapsed conservation query runtime and peak memory usage on the HLA locus (chr6:28,510,120–33,480,577) anchored to GRCh38. Note that the HLA region annotated in GRCh38 is larger than that of T2T-CHM13, explaining the higher memory footprint compared to 1. Time is expressed in hours:minutes:seconds