Method | Index - HPRC | Query - HLA Locus |
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Size (GB) | Pivot | Query Length | Query Type | Time | Memory (GB) |
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PanKmer | 23.29 | any | 31-mer only | 1, –, 3, – | 1:24:33.87 | 6.27 |
KMC3-M | 1,267.20 | any | re-index | 1, 2, 3, – | 1:31:23.07 | 14.32 |
KMC3-C | 18.05 | any | re-index | 1, –, 3, 4* | 0:00:35.71 | 18.10 |
MEMO-M | 2.35 | re-index | any | 1, 2, 3, – | 0:00:51.15 | 2.69 |
MEMO-C | 2.04 | re-index | any | 1, –, 3, – | 0:00:13.89 | 2.79 |
MEMO-DC | 0.87 | re-index | any | –, –, –, 4 | 0:00:08.12 | 2.46 |
- The pangenome includes 88 human autosomal haplotypes from HPRC and T2T-CHM13, with MEMO pivot as T2T-CHM13. Index query types include: 1. Global presence/absence; 2. Member presence/absence; 3. Conservation; 4. Decile conservation. Query type 4* indicates no relative size reduction in a KMC3 decile index. The decile conservation index yields counts to the nearest lowest decile. Elapsed conservation query runtime and peak memory usage on the HLA locus (chr6:29,476,949–33,231,258) anchored to T2T-CHM13. Time is expressed in hours:minutes:seconds