Fig. 5

Sequence conservation plot from 31-mers anchored to the T2T-CHM13 HLA locus across the HPRC haplotypes (n=88). The user specifies a target region on the pivot, a length-k, and a histogram bin count to visualize the proportion of genomes containing the k-mer at each position of the query. The white area above the stacked bars represents the proportion of k-mers found across all 89 genomes. (Top left) Zoomed-in on the HLA delta block highlights a region of low sequence diversity. (Top right) Decile resolution of the Delta block demonstrates that MEMO-DC yields a plot that’s largely indistinguishable from the full-fidelity plot made by MEMO-C